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Nimesulide oral administration increases the intraocular pressure-lowering effect of latanoprost in patients with primary open-angle glaucoma.

Costagliola C, Parmeggiani F, Caccavale A, Sebastiani A

Department of Ophthalmology, University of Ferrara, and Neuro-ophthalmology and Ocular Immunology Service, Magenta and Abbiategrasso General Hospital, Italy.

PURPOSE: To verify the short-term influence of an orally administered nonsteroidal anti-inflammatory drug on the intraocular pressure (IOP) of primary open-angle glaucoma patients in therapy with a topical prostaglandin analog. DESIGN: Randomized cross-over double-blind study. METHODS: Sixteen adults with primary open-angle glaucoma, receiving 0.005% latanoprost eyedrops once daily, were treated with a single dose of either 100 mg nimesulide or placebo. IOP was recorded at baseline and at 1, 2, 4, 8, 12, and 24 hours. RESULTS: After nimesulide administration, there was a decrease in IOP (with a fall at the second hour, P<.01) that remained significant 8 hours later (P<.05). At 12 and 24 hours, there were unremarkable IOP differences between the two regimens. CONCLUSIONS: In patients with primary open-angle glaucoma, single-dose nimesulide significantly enhances the latanoprost-induced IOP-lowering effects during the short plasma half-life of this non-steroidal anti-inflammatory drug.

Published 6 February 2006 in Am J Ophthalmol, 141(2): 379-81.
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