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Intracameral bevacizumab for iris rubeosis.

Grisanti S, Biester S, Peters S, Tatar O, Ziemssen F, Bartz-Schmidt KU,

Department of Ophthalmology I, Eberhard-Karls University of Tuebingen, Tuebingen, Germany. salvatore.grisanti@med.uni-tuebingen.de

PURPOSE: To determine whether intracameral bevacizumab decreases vascular leakage from iris rubeosis in patients with neovascular glaucoma. DESIGN: Interventional case series. METHODS: The study included six eyes of three patients with secondary neovascular glaucoma due to proliferative diabetic retinopathy (n = 2) or ischemic central retinal vein occlusion (n = 1). All patients received an intracameral injection of 1.0 mg bevacizumab. Morphologic changes and vascular leakage were investigated prospectively by iris fluorescein angiography. RESULTS: Decrease in leakage was detected as early as one day after injection. No inflammation was observed. No relapse was seen within the follow-up of four weeks. CONCLUSION: Intraocular injection of bevacizumab may provide an additional strategy for the treatment of iris rubeosis in neovascular glaucoma.

Published 3 July 2006 in Am J Ophthalmol, 142(1): 158-60.
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